Titlebook: Autoimmunity: Experimental Aspects; Moncef Zouali Conference proceedings 1994 Springer-Verlag Berlin Heidelberg 1994 Autoimmunkrankheit.Im

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Role of Immunocompetent Cells in Skin Sclerosis and Autoimmunity in Tight Skin Micesia. Although, the exact mechanisms involved in the pathogenesis of SSc are not known, the following three major alterations might play a role in the pathogenesis:.The autoimmune manifestations in scleroderma are characterized by the presence of autoantibodies as well as by abnormalities of cellular immune response.

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Tolerance induction in mature peripheral T cells T lymphocytes. The enormous diversity of the receptor repertoire is achieved by random rearrangement of DNA segments. In this process specificities for non-self as well as for self-determinants are created. T lymphocytes with high affinity for self-antigens are physically eliminated when they devel

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Transgenic mice carrying the rearranged T cell receptor of a diabetogenic T cell clonepancreatic islets of langerhans (reviewed in Castano and Eisenbarth, 1990). The genetic and environmental factors which provoke this disease in humans remain largely unknown. Fortunately, the nonobese diabetic (NOD) mouse develops a spontaneous diabetes remarkably similar to that in humans and has t

ALT

The maintenance and reestablishment of self-tolerance: T cell receptor (TCR) peptide-specific regulalerance is still unclear. Clonal deletion of self-reactive T cells during the thymic selection process has been described as one of the major mechanisms for inducing central tolerance (Kappler et al., 1987; von Boehmer, 1990). The presence of autoaggressive cells in healthy individuals as well as th

LUMEN

Prevention of gastric autoimmunity by transgenic expression of a proton pump subunit in the thymusf cells from the mucosa and submucosal lymphocytic infiltration, is the underlying basis for pernicious anaemia, the most common cause of vitamin B12 deficiency in whites of northern European origin (Gleeson and Toh, 1991; Toh et al, 1992). The gastric parietal cell appears to be the principal cell

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The Anti-Self B Cell Repertoirehe expressed V. gene repertoire of normal humans. The results of a number of different experiments suggest that the phenomenon of repertoire restriction is due to clonal selection at the level of both mature and immature B cells. For instance, in examining sequences of the over-represented V. genes

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In vivo suppression of IgG2ab production accomplished by CD4+8? Th1 cell clones specific for a γ2ab en implicated in idiotypic network immune regulation (Jerne 1974), in the pathogenesis of autoimmune diseases (Hannestad and Kristoffersen, 1988; Hannestad et al, 1992), and immune surveillance of B cell neoplasms (Lynch et al, 1972; J?rgensen et al, 1980). Furthermore, IgG Fc regions are the target

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