Titlebook: Attempts to Understand Metastasis Formation II; Regulatory Factors Ursula Günthert,Walter Birchmeier Book 1996 The Editor(s) (if applicable

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Attempts to Understand Metastasis Formation II978-3-642-61109-4Series ISSN 0070-217X Series E-ISSN 2196-9965

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0070-217X Overview: 978-3-642-64698-0978-3-642-61109-4Series ISSN 0070-217X Series E-ISSN 2196-9965

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Regulation of Tumor Angiogenesis by Organ-Specific Cytokines,ression and metastasis is vascularization of the tumor and its immediate surroundings (F. 1992). Without the ability to recruit new blood vessels, it is likely that most tumors would not grow beyond 1–2 mm and thus remain localized at the primary site. The induction of neovascularization is mediated

Angiogenesis

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Epithelial Differentiation and the Control of Metastasis in Carcinomas,nes that contribute to carcinoma formation and progression have been identified. The most frequent mutations found in carcinomas include activating mutations in the . family of genes, mutations that interfere with the function of p53, and amplification or overexpression of genes encoding tyrosine ki

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