Titlebook: Assessing Rare Variation in Complex Traits; Design and Analysis Eleftheria Zeggini,Andrew Morris Book 2015 Springer Science+Business Media

pessimism

PLE

Natural Selection at Rare Variants,copies of a dominant severely deleterious (evolutionarily lethal) rare variant are expected to represent independent mutational events and thus often lie on different haplotypes. These characteristics can potentially help to prioritize candidate causal rare variants in disease studies.