Titlebook: Aptamers in Biotechnology; Katharina Urmann,Johanna-Gabriela Walter Book 2020 The Editor(s) (if applicable) and The Author(s), under exclu

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https://doi.org/10.1007/978-1-84996-335-0d affinity of the conjugate, the nanoparticles’ function varies from signal generation in diagnostic approaches to drug loading in drug delivery systems. Within this chapter different medical applications of aptamer-modified nanoparticles will be summarized and underlying principles will be described.

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Defining Target Product Profiles (TPPs) for Aptamer-Based Diagnostics,ptamers, to produce assays with longer shelf life or special chemical properties and ability to be modified versus protein-based antibodies. The following chapter reviews the essence of well-conceived TPPs especially with respect to aptamer targets for diagnostics and illustrates several examples of commercial aptamer diagnostic success.

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