Titlebook: Apoptosis, Cell Signaling, and Human Diseases; Molecular Mechanisms Rakesh Srivastava Book 2007 Humana Press 2007 DNA.HIV.gene expression.g

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An exact and scientific metaphysicshanism to remove infected, damaged or mutated cells. Although a number of stimuli trigger apoptosis, it is mainly mediated through at least three major pathways that are regulated by (1) the death receptors, (2) the mitochondria, and (3) the ER (endoplasmic reticulum). Under certain conditions, thes

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https://doi.org/10.1007/978-3-540-31107-2ls. It was previously considered a humble garbage collector, performing housekeeping duties to remove misfolded or spent proteins. Recent findings also substantiate a pivotal role of the proteasome in the regulation of apoptosis. Polyubiquitin conjugation of key pro-and antiapoptotic molecules targe

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https://doi.org/10.1007/978-3-540-31107-2 immune response and the onset of opportunistic infections and neoplasms. The mechanism responsible of CD4 T-cell depletion is mainly the induction of apoptosis, which can be activated by HIV through various pathways. In this chapter direct and indirect mechanisms of HIV-induced apoptosis in infecte

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Quantities and Measurable Qualities,ses, to affect the controlled demise of cells. When the regulatory pathways controlling cell death are perturbed through mutation, disease states, including cancers and neurodegenerative disorders, can occur. Therefore, caspases and the molecules regulating their function are potential candidates fo

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Quantities and Measurable Qualities,anisms are activated to allow more time for effective repair. However, if these mechanisms fail or the damage is irreparable, then apoptosis is induced to eliminate cells carrying DNA lesions and preserve genomic integrity. This chapter discusses how DNA damage-dependent apoptosis is induced and executed.

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