Titlebook: Androgens and Androgen Receptor; Mechanisms, Function Chawnshang Chang Book 2002 Kluwer Academic Publishers 2002 DNA.autoimmune disease.can

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Androgen Insensitivity Syndrome (Testicular Feminization),ncy, and 2) defects in androgen action. The second category includes 5α-reductase deficiency (pseudovaginal perineoscrotal hypospadias) and androgen insensitivity (or resistance) syndrome. Formerly, the severest type of the androgen insensitivity syndrome was called testicular feminization syndrome.

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Structural and Functional Analysis of the Androgen Receptor,ediate the expression of target genes in response to ligands specific to each receptor, including steroids, retinoids, vitamin D, and thyroid hormone. Members of the nuclear receptor superfamily all share a common structure composed of an NH.-terminal transactivation domain and DNA and ligand bindin