Titlebook: Analgesia; Christoph Stein Book 2007 Springer-Verlag Berlin Heidelberg 2007 Arthritis.Cancer.Cannabinoid.Headache.Inflammation.Opioid.Pain

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Adrenergic and Cholinergic Compounds-established analgesic profile; however, recent investigations suggest that this class of agents is underused, and herein we highlight the potential for both current application and future development of these agents. Nicotinic and muscarinic cholinergic ligands represent a novel class of agents wit

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Cannabinoids and Pains. The anatomical and functional data reveal cannabinoid receptor-mediated analgesic actions operating at sites concerned with the transmission and processing of nociceptive signals in brain, spinal cord and the periphery. The precise signalling mechanisms by which cannabinoids produce analgesic eff

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Adenosine and ATP Receptorsions. Such influences reflect peripheral and central actions and effects on neurons as well as other cell types. In general, adenosine A1 receptors produce inhibitory effects on pain in a number of preclinical models and are a focus of attention. In humans, i.v. infusions of adenosine reduce some as

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Ion Channels in Analgesia Researchmolecular nature of the channels that are activated by tissue-damaging stimuli, as well as the mechanisms by which voltage-gated channels alter the sensitivity of peripheral neurons to change pain thresholds. This chapter details the evidence that individual channels may be associated with particula

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Protein Kinases as Potential Targets for the Treatment of Pathological Painathological pain is an expression of neural plasticity that occurs both in the peripheral nervous system (e.g., primary sensory nociceptors), termed peripheral sensitization, and in the central nervous system (e.g., dorsal horn and brain neurons), termed central sensitization. Our insufficient under

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Christoph SteinIncludes supplementary material:

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Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/a/image/155791.jpg

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Analgesia978-3-540-33823-9Series ISSN 0171-2004 Series E-ISSN 1865-0325

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Bernhard Ebbinghaus,Jelle Visserortantly, both the peripheral and the central nociceptive system contribute significantly to the generation of pain upon inflammation and nerve injury. Peripheral nociceptors are sensitized during inflammation, and peripheral nerve fibres develop ectopic discharges upon nerve injury or disease. As a