Titlebook: Advances in Rapid Sex-Steroid Action; New Challenges and N Gabriella Castoria,Antimo Migliaccio Book 2012 Springer Science+Business Media,

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Explaining Medical Model Exceptions (ADT) represents a good therapeutic tool for the treatment of PCa patients, but after an initial period of remission, the disease progresses towards an androgen-independent (AI) state. While in androgen-dependent (AD) stage the roles of androgens and their receptor (AR) are fully described inAI, th

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Studies in Computational Intelligence-like growth factors (IGF) I and II plays a role in the development and progression of a variety of malignancies, including prostate cancer. Recent studies indicate that membrane-initiated effects of both androgens and estrogens provide a non-mutational mechanism for marked IGF-IR upregulation in pr

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S Spelmen Vimalraj,Porkodi Rajendranan exquisite sensitivity to androgen deprivation therapy and is the most endocrine-sensitive solid neoplasm, although the disease may eventually progress to the castration-resistant status (CRPC). However, recent evidence was provided that the cancer progression at the CRPC stage is often mediated b

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https://doi.org/10.1007/978-3-642-30621-1have provided deep insights into NR function but, due to their nature as single endpoint assays derived from pooled cell populations and tissues, these approaches are intrinsically unable to address important mechanistic considerations linked to cellular heterogeneity. Androgen receptor (AR) and est

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Mattia Broilo,Francesco G. B. De Natalelter gene expression. These processes typically take at least 30 to 60 min for an increase in mRNA expression to be observed. In contrast, other regulatory actions of steroid hormones such as increases in activity of mitogen activated protein kinases are manifested within seconds to a few minutes an

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Cosmin Danut Bocaniala,José Sá da Costasic model of steroid hormone action as restricted to classic cell types rather than valid for all steroid target cells. Cross talk between membrane receptors and nuclear steroid receptors regulates nuclear steroid receptor action. An additional cross talk occurring between membrane receptors and ext

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