Titlebook: Advances in Eicosanoid Research; C. N. Serhan,H. D. Perez Conference proceedings 2000 Springer-Verlag Berlin Heidelberg 2000 Anti-Inflamma

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https://doi.org/10.1007/3-540-56253-2is highly unstable epoxide may undergo enzymatic hydrolysis into the dihydroxy acid LTB. or may be conjugated with glutathione to form LTC.. These two reactions are catalyzed by LTA. hydrolase and LTC. synthase, respectively.

implore

Dimitrios S. Dendrinos,Michael Sonis Leslie 1997; Uozumi et al. 1997). We isolated arachidonate 5-lipoxygenase from potato tubers for the first time and found that a single enzyme catalyzes both lipoxygenation and dehydration to yield LTA. (Shimizu et al. 1984).

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Conference proceedings 2000for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro- stacyclin are being tested for the treatment of peripheral vascular dis- ease, and selective inhibitors of cyclooxygenase type II were just ap- proved for the treatmen

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https://doi.org/10.1007/978-3-642-68304-6s PGHS-1 forms products that are involved in “housekeeping” functions when circulating hormones act on cells acutely to cause the release of higher concentrations of arachidonate (Capdevila et al. 1995; Kulmacz and Wang 1995; Kulmacz 1998; So et al. 1998).

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Conference proceedings 2000nd pathways elucidated and new therapeutic approaches have emerged. The concept of ei- cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.