Titlebook: Wirtschaftliche Implikationen des demografischen Wandels; Herausforderungen un Michael G?ke,Thomas Heupel Conference proceedings 2013 Sprin

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Artificial Pancreas to Treat Type 1 Diabetes Mellitus,, immunoprotection strategies, and biocompatibility of the islet-cell-containing microbarriers, as well as to approaches to ameliorate these features. Currently available BHAP prototypes have been critically reviewed to define expectations about the next generation devices targeting the final cure of T1DM.

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Cytokine-neutralizing therapeutic antibodies,mmunogenicity can be reduced using human Mabs produced, for example, by phage display or to humanise or CDR graft a mouse antibody. This reduces the number of mouse residues in the Mab to about 12–15%, the vast majority of which are contained in the CDR regions. Such engineered human antibodies are

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